How easy is it to get provocative findings using mainstream methods published? Well, it depends on how provocative. Here’s a second round of generally nonsensical reviews for our PING paper (which you can read here and judge yourself: a good chunk of readers of this blog are themselves researchers and don’t need others to review […]

Readers will perhaps recall that I tried to come up with some metrics for the polygenicity of a trait back in 2016. Well, there’s a new preprint now: Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits and implications for the future Summary-level statistics from genome-wide association studies […]

There’s a highly interesting new paper out: The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities (Mendelians are also known as monogenic disorders because they are inherited in patterns that follow Mendel’s laws.) Abstract: Discovering the genetic basis of a Mendelian phenotype establishes a causal link between genotype and phenotype, making possible carrier and […] Gwern has a very long and detailed post/page on embryo selection and related matters. You should definitely read it. He has just added a new section on counteracting dysgenics — the genetic evolution of undesirable traits — and asked for my comments/thoughts. The background for the discussion are the recent genomic findings supporting dysgenic […]

Doing some background reading on genomics topics such as: Cross-population predictive validity of genomic scores (polygenic scores). LD-decay. Causal variant tagging / distribution of causal variants / genetic architecture. Admixture mapping accuracy given LD decay. Implications of the above for research into genetic causes of group differences in polygenic traits. Implications of the above for […]

(See 2015 post) There’s a very interesting new preprint out: Heterogeneity in polygenic scores for common human traits Erin B Ware, Lauren L Schmitz, Jessica D Faul, Arianna Gard, Colter Mitchell, Jennifer A Smith, Wei Zhao, David Weir, Sharon LR Kardia bioRxiv 106062; doi: This study investigates the creation of polygenic scores (PGS)s for […]