www.gwern.net/Embryo%20selection#counteracting-dysgenics Gwern has a very long and detailed post/page on embryo selection and related matters. You should definitely read it. He has just added a new section on counteracting dysgenics — the genetic evolution of undesirable traits — and asked for my comments/thoughts. The background for the discussion are the recent genomic findings supporting dysgenic […]

Comment on: infoproc.blogspot.dk/2016/02/missing-heritability-and-gcta-update-on.html First, skim this paper: journals.plos.org/ploso… Genomic prediction works fairly well. This recent paper does a cross-data cross-method analysis of genomic prediction methods using 10 fold cross-validation to account for overfitting. In general, the compressed sensing/lasso/regularization methods perform well, but surprisingly an even simpler method comes out on top (mRMR): Maximum Relevancy Minimum […]

Link: www.gwern.net/Embryo%20selection Embryo selection an add-on to IVF [his summary]: harvest x eggs fertilize them and create x embryos culture the embryos to either cleavage (2-4 days) or blastocyst (5-6 days) stage; of them, y will still be alive & not grossly abnormal freeze the embryos optional: embryo selection using quality and PGS unfreeze & […]

Abstract I review recent findings in human behavioral genetics and their implications for selective breeding and estimation of genotypic racial differences in polygenic traits. 1. Polygenic scores from all SNPs vs. p<α SNPs A recent paper (1) used polygenic scores derived from the Rietveld results (2) to score a non-overlapping sample of European Americans (EA) […]

Reading up on the huge animal breeding literature gives a useful background to one’s thinking about what selection on humans will do in the future (embryo selection and direct editing á la CRISPR). I made the above infograph some time ago, maybe 1-2 years. It is still pretty accurate. The newest data for genome sequencing […]

Kuliev, Anver, and Yury Verlinsky. “Preimplantation diagnosis: a realistic option for assisted reproduction and genetic practice.” Current Opinion in Obstetrics and Gynecology 17.2 (2005): 179-183. Preimplantation diagnosis a realistic option for assisted reproduction and genetic practice Purpose of review Preimplantation genetic diagnosis (PGD) allows genetically disadvantaged couples to reproduce, while avoiding the birth of children […]