Mainstreamers keep making progress: educational attainment variation “likely” caused by ancestry variation in Europe

Lawson, D. J., Davies, N. M., Haworth, S., Ashraf, B., Howe, L., Crawford, A., … & Timpson, N. J. (2020). Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?. Human genetics, 139(1), 23-41. Replicable genetic association signals have consistently been found through genome-wide association studies in recent years. The recent…

Continue Reading

Species genetic variation and number of subspecies/races/breeds/breeding populations/clusters etc.

A straightforward research idea: Compare the recognized count of subspecies (races/breeds/breeding populations/clusters etc.) with measures of genetic variation. The most obvious is the Fst but it’s not an optimal metric. There is some literature on this: Woodley, M. A. (2010). Is Homo sapiens polytypic? Human taxonomic diversity and its implications. Medical hypotheses, 74(1), 195-201. Fuerst,…

Continue Reading

A partial test of DUF1220 for population differences in intelligence?

You might have heard the DUF1220 hypothesis, it goes something like this: DUF1220 is a copy number variant poorly tagged by arrays, and thus would not be captured well by typical GWASs for education/IQ. Comparative species data suggests strong selection for DUF1220 with increased intelligence/brain size. There’s some data showing a relationship between IQ in…

Continue Reading

Updated 23andme results (2019-01-22)

Previous results. 23andme has updated their ancestry estimates, so I’m reposting mine for people who are wondering. The change to previously is that now I’m slightly more European: 99.8% vs. 99.7%. I’m no longer North African, but now I’m 0.1% Amerindian (false positive probably), and less Ashkenazi 2.8% (from 2.9%). They also report regional results…

Continue Reading

Lewontin’s famous 1972 book chapter

Few people actually read this, which is a shame because the science is interesting for historical purposes, and the fulltext of his famous fallacy is rarely read. I believe this is a pity because it is really obvious when you actually read it. Lewontin, R. C. (1972). “The Apportionment of Human Diversity”. Evolutionary Biology. pp….

Continue Reading

SQL server for population frequencies from 1000 genomes

Note: 2018 June 26 Server down right now, investigating. Note: August 16, 2017 server IP changed to 67.207.92.10. Original post We need dplyr for this: library(dplyr) First, use the anon user to log into the SQL server (user = “anon”, pass = “”, ip = “67.207.92.10”, port = 3306): sql = src_mysql(“population_freqs”, host = “67.207.92.10”,…

Continue Reading