Polygenic traits and the distribution of effect sizes: years of education from Rietveld et al (2013)

It is often said that polygenic traits are based on tons of causal variants each of which has a very small effect size. What is less often discussed is the distribution of these effect sizes, although this has some implications. The first statistical importance is that we may want to modify our hyperprior if using…

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Empirical math, or how experiments can increase our confidence in mathematical conclusions despite access to formal proofs

Earlier posts: Something about certainty, proofs in math, induction/abduction, Is the summed cubes equal to the squared sum of counting integer series? The things I’m going to say for math are equally true for logic, so whenever I write “math”, just mentally substitute to “math and logic”. Here I’m going to be talking about something…

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Researcher degrees of freedom as sensitivity analysis

https://en.wikipedia.org/wiki/Sensitivity_analysis Researcher degrees of freedom refer to the choices researchers make when conducting a study. There are many choices to be made, where to collect data, which variables to include, etc. However, a large subset of the choices concern only the question of how to analyze the data. Still I have now done 100s of…

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