Admixture mapping assisted GWAS

Medical researchers have noticed that some diseases differ by SIRE (self-identified race/ethnicity) groups which differ by genomic (racial) ancestry. Hence, when genomic measures became available (last 15 years or so), they measured peoples relative proportions of ancestry in mixed populations to see if the diseases would be predictable by ancestry. They were. This establishes with…

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Does genomic prediction work?

Comment on: http://infoproc.blogspot.dk/2016/02/missing-heritability-and-gcta-update-on.html First, skim this paper: http://journals.plos.org/ploso… Genomic prediction works fairly well. This recent paper does a cross-data cross-method analysis of genomic prediction methods using 10 fold cross-validation to account for overfitting. In general, the compressed sensing/lasso/regularization methods perform well, but surprisingly an even simpler method comes out on top (mRMR): Maximum Relevancy Minimum…

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Comments on Gwern’s “Embryo selection for intelligence”

Link: http://www.gwern.net/Embryo%20selection Embryo selection an add-on to IVF [his summary]: harvest x eggs fertilize them and create x embryos culture the embryos to either cleavage (2-4 days) or blastocyst (5-6 days) stage; of them, y will still be alive & not grossly abnormal freeze the embryos optional: embryo selection using quality and PGS unfreeze &…

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Comments on Noah Carl’s new study: IQ and socio-economic development across local authorities of the UK

Paper is on Scihub. There are a few researchers engaged in the cognitive sociology adventure. Aside from myself and John Fuerst, Noah Carl has also taken up the task. There is of course also Richard Lynn, the grand old man of these studies (publishing his first in 1979). Mostly the job of doing these analyses…

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Causality, transitivity and correlation

Disclaimer: Some not too structured thoughts. It’s commonly said that correlation does not imply causation. That is true (see Gwern’s analysis), but does causation imply correlation? Specifically, if “→” means causes and “~~” means correlates with, does X→Y imply X~~Y? It may seem obvious that the answer is yes, but it is not so clear….

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Stereotypes are relevant for judgments about individuals even when one has individualized information

Title says it all. Apparently, some think this is not the case, but it is a straightforward application of Bayes’ theorem. When I first learned of Bayes’ theorem years ago, I thought of this point. Back then I also believed that stereotypes are irrelevant when one has individualized information. Alas, it is incorrect. Neven Sesardic…

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Differential measurement error and regression

In reviewing our upcoming target article in Mankind Quarterly (edit: now published), Gerhard Meisenberg wrote: “One possibility that you don’t seem to discuss is that there are true and large correlations of the Euro% variable and the geographic variables, but that the geographic variables are measured much more precisely than the Euro% variable. In that…

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