Q/A with Antonio Regalado for genomics

Antonio Regalado is providing us with a recent series of the arguably best informed (compared to Guardian, Nature news etc.) popular science articles on genomics and its relevance to modern eugenics (embryo selection or genetic engineering) as well as the group differences causation question. www.technologyreview.com/s/609204/eugenics-20-were-at-the-dawn-of-choosing-embryos-by-health-height-and-more/ www.technologyreview.com/s/610251/forecasts-of-genetic-fate-just-got-a-lot-more-accurate/ www.technologyreview.com/s/610339/dna-tests-for-iq-are-coming-but-it-might-not-be-smart-to-take-one/ As background for some of these, I had…

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“This manuscript addresses a politically sensitive issue that I would prefer not to include in Frontiers in Evolutionary Sociology and Biosociology.”

While I am re-writing our PING study to become a substantial target article, John is sending it to various journals in the mean time to poke about their editorial biases. Here’s a recent reply, which was thankfully quite up front about the bias: From: Frontiers <noreply@frontiersin.org> Sent: Monday, September 25, 2017 5:05 PM To: j122177@hotmail.com

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Estimating the polygenicity of traits: an update

Readers will perhaps recall that I tried to come up with some metrics for the polygenicity of a trait back in 2016. Well, there’s a new preprint now: Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits and implications for the future Summary-level statistics from genome-wide association studies…

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There’s a lot more to the Mendelians

There’s a highly interesting new paper out: The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities (Mendelians are also known as monogenic disorders because they are inherited in patterns that follow Mendel’s laws.) Abstract: Discovering the genetic basis of a Mendelian phenotype establishes a causal link between genotype and phenotype, making possible carrier and…

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Comments on Gwern’s Counteracting Dysgenics

www.gwern.net/Embryo%20selection#counteracting-dysgenics Gwern has a very long and detailed post/page on embryo selection and related matters. You should definitely read it. He has just added a new section on counteracting dysgenics — the genetic evolution of undesirable traits — and asked for my comments/thoughts. The background for the discussion are the recent genomic findings supporting dysgenic…

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Some genomics papers I read recently

Doing some background reading on genomics topics such as: Cross-population predictive validity of genomic scores (polygenic scores). LD-decay. Causal variant tagging / distribution of causal variants / genetic architecture. Admixture mapping accuracy given LD decay. Implications of the above for research into genetic causes of group differences in polygenic traits. Implications of the above for…

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On the validity of polygenic scores, in general and in Africans

(See 2015 post) There’s a very interesting new preprint out: Heterogeneity in polygenic scores for common human traits Erin B Ware, Lauren L Schmitz, Jessica D Faul, Arianna Gard, Colter Mitchell, Jennifer A Smith, Wei Zhao, David Weir, Sharon LR Kardia bioRxiv 106062; doi: doi.org/10.1101/106062 This study investigates the creation of polygenic scores (PGS)s for…

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