{"id":4016,"date":"2013-11-04T21:23:35","date_gmt":"2013-11-04T20:23:35","guid":{"rendered":"http:\/\/emilkirkegaard.dk\/en\/?p=4016"},"modified":"2014-10-09T18:50:29","modified_gmt":"2014-10-09T17:50:29","slug":"preimplantation-genetic-diagnosis-embryo-slection","status":"publish","type":"post","link":"https:\/\/emilkirkegaard.dk\/en\/2013\/11\/preimplantation-genetic-diagnosis-embryo-slection\/","title":{"rendered":"Preimplantation genetic diagnosis, embryo slection"},"content":{"rendered":"
Kuliev, Anver, and Yury Verlinsky. “Preimplantation diagnosis: a realistic option for assisted reproduction and genetic practice.” Current Opinion in Obstetrics and Gynecology<\/em> 17.2 (2005): 179-183.<\/div>\n
Preimplantation diagnosis a realistic option for assisted reproduction and genetic practice<\/a><\/div>\n
<\/div>\n
Purpose of review<\/span>
\nPreimplantation genetic diagnosis (PGD) allows genetically<\/span>
\ndisadvantaged couples to reproduce, while avoiding the<\/span>
\nbirth of children with targeted genetic disorders. By<\/span>
\nensuring unaffected pregnancies, PGD circumvents the<\/span>
\npossible need and therefore risks of pregnancy termination.<\/span>
\nThis review will describe the current progress of PGD for<\/span>
\nMendelian and chromosomal disorders and its impact on<\/span>
\nreproductive medicine.<\/span>
\nRecent \ufb01ndings<\/span>
\nIndications for PGD have expanded beyond those used in<\/span>
\nprenatal diagnosis, which has also resulted in improved<\/span>
\naccess to HLA-compatible stem-cell transplantation for<\/span>
\nsiblings through preimplantation HLA typing. More than<\/span>
\n1000 apparently healthy, unaffected children have been<\/span>
\nborn after PGD, suggesting its accuracy, reliability and<\/span>
\nsafety. PGD is currently the only hope for carriers of<\/span>
\nbalanced translocations. It also appears to be of special<\/span>
\nvalue for avoiding age-related aneuploidies in in-vitro<\/span>
\nfertilization patients who have a particularly poor prognosis<\/span>
\nfor a successful pregnancy; the accumulated experience of<\/span>
\nthousands of PGD cycles strongly suggests that PGD can<\/span>
\nimprove clinical outcome for such patients.<\/span>
\nSummary<\/span>
\nPGD would particularly bene\ufb01t poor prognosis in-vitro<\/span>
\nfertilization patients and other at-risk couples by improving<\/span>
\nreproductive outcomes and avoiding the birth of affected<\/span>
\noffspring.<\/span><\/div>\n
<\/div>\n
<\/div>\n
\n
Verlinsky, Yury, et al. “Over a decade of experience with preimplantation genetic diagnosis: a multicenter report.” Fertility and sterility<\/em> 82.2 (2004): 292-294.<\/div>\n<\/div>\n
Over a decade of experience with preimplantation genetic diagnosis a multicenter report<\/a><\/div>\n
<\/div>\n
\n
Harper, Joyce C., and Sioban B. SenGupta. “Preimplantation genetic diagnosis: state of the art 2011.” Human genetics<\/em> 131.2 (2012): 175-186.<\/div>\n<\/div>\n
Preimplantation genetic diagnosis State of the ART 2011<\/a><\/div>\n
<\/div>\n
I made this:<\/div>\n
\"\"<\/div>\n","protected":false},"excerpt":{"rendered":"

Kuliev, Anver, and Yury Verlinsky. “Preimplantation diagnosis: a realistic option for assisted reproduction and genetic practice.” Current Opinion in Obstetrics and Gynecology 17.2 (2005): 179-183. Preimplantation diagnosis a realistic option for assisted reproduction and genetic practice Purpose of review Preimplantation genetic diagnosis (PGD) allows genetically disadvantaged couples to reproduce, while avoiding the birth of children […]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1690,1727,1107],"tags":[2018,1912],"class_list":["post-4016","post","type-post","status-publish","format-standard","hentry","category-genetics","category-medicine","category-science","tag-embryo-selection","tag-eugenics-genetics","entry"],"_links":{"self":[{"href":"https:\/\/emilkirkegaard.dk\/en\/wp-json\/wp\/v2\/posts\/4016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/emilkirkegaard.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/emilkirkegaard.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/emilkirkegaard.dk\/en\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/emilkirkegaard.dk\/en\/wp-json\/wp\/v2\/comments?post=4016"}],"version-history":[{"count":2,"href":"https:\/\/emilkirkegaard.dk\/en\/wp-json\/wp\/v2\/posts\/4016\/revisions"}],"predecessor-version":[{"id":4374,"href":"https:\/\/emilkirkegaard.dk\/en\/wp-json\/wp\/v2\/posts\/4016\/revisions\/4374"}],"wp:attachment":[{"href":"https:\/\/emilkirkegaard.dk\/en\/wp-json\/wp\/v2\/media?parent=4016"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/emilkirkegaard.dk\/en\/wp-json\/wp\/v2\/categories?post=4016"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/emilkirkegaard.dk\/en\/wp-json\/wp\/v2\/tags?post=4016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}