Q/A with Antonio Regalado for genomics
Antonio Regalado is providing us with a recent series of the arguably best informed (compared to Guardian, Nature news etc.) popular science articles on genomics and its relevance to modern…
“This manuscript addresses a politically sensitive issue that I would prefer not to include in Frontiers in Evolutionary Sociology and Biosociology.”
While I am re-writing our PING study to become a substantial target article, John is sending it to various journals in the mean time to poke about their editorial biases.…
Some more reviews for our PING paper
How easy is it to get provocative findings using mainstream methods published? Well, it depends on how provocative. Here's a second round of generally nonsensical reviews for our PING paper…
Estimating the polygenicity of traits: an update
Readers will perhaps recall that I tried to come up with some metrics for the polygenicity of a trait back in 2016. Well, there's a new preprint now: Estimation of…
There’s a lot more to the Mendelians
There's a highly interesting new paper out: The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities (Mendelians are also known as monogenic disorders because they are inherited in patterns…
Comments on Gwern’s Counteracting Dysgenics
https://www.gwern.net/Embryo%20selection#counteracting-dysgenics Gwern has a very long and detailed post/page on embryo selection and related matters. You should definitely read it. He has just added a new section on counteracting dysgenics…
Some genomics papers I read recently
Doing some background reading on genomics topics such as: Cross-population predictive validity of genomic scores (polygenic scores). LD-decay. Causal variant tagging / distribution of causal variants / genetic architecture. Admixture…
On the validity of polygenic scores, in general and in Africans
(See 2015 post) There's a very interesting new preprint out: Heterogeneity in polygenic scores for common human traits Erin B Ware, Lauren L Schmitz, Jessica D Faul, Arianna Gard, Colter…
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