Metrics for quantifying genetic cardinality of a trait
It is common to talk about traits being monogenic or polygenic. We say that Sickle-cell disease is monogenic because its heritable variation among humans can be accounted for by a…
Polygenic traits and the distribution of effect sizes: years of education from Rietveld et al (2013)
It is often said that polygenic traits are based on tons of causal variants each of which has a very small effect size. What is less often discussed is the…
Polygenic scores, genetic engineering, validity of GWAS results across major racial groups and the Piffer method
A PDF of this paper without formatting errors can be downloaded here. Abstract I review recent findings in human behavioral genetics and their implications for selective breeding and estimation of…